Deletion-Mutant mtDNA Increases in Somatic Tissues but Decreases in Female Germ Cells With Age
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چکیده
منابع مشابه
Deletion-mutant mtDNA increases in somatic tissues but decreases in female germ cells with age.
The proportions of mutant and wild-type mtDNA are crucial in determining the severity of mitochondrial diseases. It has been generally considered that deletion-mutant mtDNA has replication advantages and accumulates with time. Here, we examine the tissue-by-tissue proportions of mutant mtDNA with a 4696-bp deletion (DeltamtDNA) and wild-type mtDNA in mitochondrial disease model mice (mito-mice)...
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ژورنال
عنوان ژورنال: Genetics
سال: 2007
ISSN: 1943-2631
DOI: 10.1534/genetics.107.081026